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Some of the risks include cardiovascular issues, such as an increased risk of heart disease or stroke. Like any treatment, TRT comes with potential risks, especially when used long-term. However, the long-term effects of TRT on injury recovery are not entirely clear. Keeping your muscles strong and your bones dense can help prevent further injuries and make it easier for your body to recover fully. Some studies suggest that TRT can help maintain muscle strength and bone density over the long term. By combining TRT with other treatments, patients can optimize their recovery and improve their chances of a full return to health. 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(1999) found an early increase in proliferation and procollagen synthesis in freshly isolated ACL cells that were incubated with estrogen (Lee H. et al., 2015). With evidence pointing to hormonal fluctuations of the menstrual cycle having an influence on ligament injury risk, the question of how sex hormones, estrogen in particular, increase the risk of injury has been the focus of study. Proper training, nutrition, and rest are also crucial components of injury prevention. It’s important to gradually increase physical activity and monitor your body’s response. However, it's important to monitor joint health as hormone fluctuations can also affect joint comfort. TRT is unlikely to worsen an existing injury, but improper use or dosing could lead to complications such as overtraining or [https://git.cultist.gay/sidneylemessur](https://git.cultist.gay/sidneylemessur) aggravation of the injury. 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